Part 8: Protecting Your Investment – The Ultimate Storage Guide for Botox, Fillers, and Skin Boosters

You have purchased high-quality aesthetic products, but their potency is not guaranteed if they are stored incorrectly. Medical aesthetics products are biological or chemical compounds sensitive to temperature, light, and humidity. Incorrect storage can lead to protein denaturation, phase separation, or bacterial contamination, rendering the product ineffective or unsafe.

Whether you are a clinic stocking inventory or a distributor, following these strict storage protocols is essential to maintain product integrity.

1. Botulinum Toxins (Botox): The "Cold Chain" Rule

Botulinum toxin is a temperature-sensitive protein. Heat is its worst enemy, capable of denaturing the protein and destroying its potency.

Unopened Vials (Lyophilized Powder): Most Korean toxins (e.g., Botulax, Nabota) come as a freeze-dried powder. They must be stored in a refrigerator at 2°C to 8°C (35.6°F - 46.4°F).
- Note: While some stabilized toxins claim heat resistance, maintaining the cold chain is the safest industry standard to guarantee maximum efficacy.
Liquid Toxins (Pre-mixed): Products like Innotox are liquid. These are highly sensitive and must strictly adhere to the 2°C to 8°C range.
After Reconstitution (Mixed with Saline): Once mixed, the solution is extremely unstable. It must be kept refrigerated and used within 24 hours (according to official labeling) to prevent bacterial growth and loss of potency.

2. Dermal Fillers (HA): The "Do Not Freeze" Rule

Hyaluronic Acid (HA) fillers (e.g., Neuramis, Revolax) have different requirements. Unlike toxins, cold is not always better.

Ideal Temperature: Store at room temperature, typically between 2°C and 25°C (35.6°F - 77°F).
CRITICAL WARNING - NO FREEZING: You must never freeze HA fillers. Freezing causes the water in the gel to crystallize, which breaks the cross-linking structure of the hyaluronic acid. If a filler freezes and thaws, the gel texture becomes uneven, leading to clumping or rapid degradation after injection.
Sunlight: Keep strictly away from direct sunlight. UV rays can degrade the HA polymer chains.

3. Skin Boosters (PN, PDRN, Exosomes)

Storage depends on the active ingredients.

PN / PDRN (e.g., Rejuran): These are heat-stable DNA fragments. They can generally be stored at room temperature (1°C to 30°C). However, keeping them in a cool, dry cabinet away from heat sources is recommended.
Exosomes:
- Lyophilized (Powder): Generally stable at room temperature but should be kept cool.
- Liquid Types: Some liquid exosome products require refrigeration or even freezing. Always check the manufacturer's package insert as exosome stability varies significantly by brand.

4. General Best Practices for All Inventory

Avoid Temperature Fluctuations: Do not store products near windows, heaters, or air conditioning vents. Consistent temperature is key.
Physical Integrity: Store boxes upright when possible. Do not stack heavy objects on top of filler boxes, as pressure can damage the syringe plunger or cause leakage.
Visual Check: Before use, inspect the product. If an HA filler looks cloudy or separated, or if a toxin vial is cracked, discard it immediately.

The efficacy of a procedure starts with how the product was handled before it even touched the skin.

Botox: Keep it cold (Fridge).
Fillers: Keep it cool/room temp (Never Freeze).
Boosters: Follow the label (Usually Room Temp).

At K-station, we prioritize strict quality control during shipping. Once the product reaches you, following these guidelines will ensure you get the 100% performance you paid for.

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