Biostimulators

Collagenesis-Enabled Solubilized Active and Biodegradable Polymer technology enables PCL to be fully solubilized in water without microparticles, unlike traditional PCL fillers.

GOURI spreads naturally into the surrounding tissue due to its liquid nature and acts as a "Fundamental Anti-Aging" treatment. It biodegrades slowly while stimulating fibroblasts to synthesize new collagen (Neocollagenesis).

• Intense Collagenesis: Stimulation of the skin's natural collagen production.
• Skin Rejuvenation & Lifting: Improvements in skin elasticity, texture, and firmness.
• Wrinkle Reduction: Softens fine lines and deep wrinkles (e.g., crow's feet, marionette lines).
• Natural Volume: Restores volume loss gradually through natural collagen buildup.

Typically requires 2mL (2 syringes) per session for full-face coverage (1mL per side).

Can be safely used for the eye area due to its liquid spreadability.

Mild swelling (edema) is common for 2–3 days post-injection due to the collagenesis inflammatory response. Redness, bruising, or tenderness may occur.

• Avoid heavy makeup for 24 hours.
• Avoid sauna, alcohol, and strenuous exercise for 1 week.

What is GOURI used for?

GOURI is a liquid-type PCL injectable used as a fundamental anti-aging treatment. It stimulates natural collagen production, rejuvenates and lifts skin, softens fine lines and deep wrinkles, and restores natural volume gradually.

What is the key ingredient?

The key ingredient is Polycaprolactone (PCL) at 210mg/mL (21%), delivered as a fully solubilized, microparticle-free liquid using CESABP technology.

How long do results last?

Visual improvements often start within 1–2 weeks, and results typically last 6–12 months as the PCL degrades naturally. The standard cycle is 3 sessions spaced 4 weeks apart, with maintenance of 1–2 sessions every 6–12 months.

Who should administer GOURI?

GOURI is a Class III medical device administered by injection into the deep dermis to subcutaneous layer using a 30G to 35G needle, and should be administered by a qualified medical professional.

Who manufactures GOURI?

GOURI is manufactured by Dexlevo Inc.

• PLLA (Poly-L-Lactic Acid): Derived from Alpha Hydroxy Acid, specifically sourced from plant-based materials like corn and sugarcane.
• CMC (Carboxymethylcellulose): Provides immediate volume upon injection.

Dual-Action Formula: CMC provides instant volume and smoothing upon injection. Over time, PLLA gradually breaks down to stimulate natural collagen regeneration (neocollagenesis). PLLA is completely metabolized by the body into carbon dioxide, water, and simple sugars, leaving no residue behind.

• Immediate plumping and smoothing of the skin via CMC.
• Long-term skin rejuvenation and progressive collagen regeneration via PLLA.
• Restoration of facial and body structure with improved skin elasticity and firmness.

Immediate visible volume from CMC. Natural collagen generation develops over several months, with results lasting up to 2 years.

Typically 24-36 months from the manufacturing date. Single-use vial only; discard any remaining product immediately after use.

• Avoid using the sauna, swimming pool, or gym for at least 7 days after treatment.
• Avoid vigorous facial treatments or massages for 2 weeks post-injection (except for the prescribed 5-5-5 gentle massage).
• Maintain a healthy lifestyle to support optimal collagen production.

It is a collagen biostimulator for immediate plumping and long-term skin rejuvenation, restoring facial and body structure with improved elasticity and firmness.

PLLA (Poly-L-Lactic Acid), a plant-based collagen stimulator sourced from corn and sugarcane, combined with CMC (Carboxymethylcellulose) for immediate volume.

Rejuva Lume is a lyophilized powder and must be reconstituted before use: add Sterile Water for Injection and agitate until a uniform, lump-free suspension forms, following the dilution volume and hydration time in the manufacturer's Instructions for Use.

There is immediate visible volume from CMC, while natural collagen generation develops over several months, with results lasting up to 2 years.

Strictly for professional medical use, injected subcutaneously or into the deep dermis with an 18G cannula or 25-27G needle; do not inject intravascularly.

It is manufactured by Phace Global Co., Ltd.

PLA (Poly-L-Lactic Acid), PN (Polynucleotides), NAD-(NMN), HA (Hyaluronic Acid), Niacinamide, Vitamin B2, and Succinic Acid.

A multi-modal biostimulator that shifts beyond simple filling by delivering instant improvements in skin quality alongside long-lasting structural remodeling and cellular repair.

• Immediate deep hydration and radiant glow.
• Long-term structural volumization and increased dermal density.
• Skin regeneration and enhanced cellular energy.
• Brightening and antioxidant protection.

• Face: Neck wrinkles, forehead lines, frown lines, crow's feet, and marionette lines.
• Eyes: Dark circles, eye wrinkles, and eye bags.
• Body: Wrinkle care, tightening, cellulite, stretch marks, and brightening for areas like hands, knees, elbows, and armpits.

Onset: Immediate hydration and optical smoothness from HA.
Duration: Gradual accumulation of new collagen and elastin over weeks to months, providing long-term volumization.

Typically 24-36 months from the manufacturing date. Once reconstituted, the solution should be used immediately.

• Side Effects: Mild swelling, redness, bruising, or tenderness at the application sites.
• Post-Care: Apply sunscreen diligently. Avoid excessive heat exposure (e.g., saunas) and strenuous physical activity for a few days post-treatment.

It is a multi-modal biostimulator for immediate hydration and glow, long-term structural volumization, skin regeneration, and brightening across the face, eyes, and body.

PLA (Poly-L-Lactic Acid), PN (Polynucleotides), NAD-(NMN), HA (Hyaluronic Acid), Niacinamide, Vitamin B2, and Succinic Acid.

Shake the vial by hand for 1 minute to reconstitute the lyophilized powder; once reconstituted, the solution should be used immediately.

Strictly for professional medical and aesthetic use, administered into the dermal/subcutaneous layer; do not inject intravascularly.

PLLA microparticles stimulate the body's natural collagen production (neocollagenesis) by activating fibroblasts. As the PLLA is gradually absorbed and metabolized by the body, the newly formed collagen restores lost facial volume and improves overall skin elasticity.

Composed of a biodegradable and biocompatible synthetic polymer designed to act as a biostimulator rather than a traditional volumizing filler.

• Gradual and natural-looking volume restoration.
• Deep wrinkle correction.
• Long-term collagen regeneration.
• Improvement of overall skin tone and texture.

Facial contouring, deep wrinkles (e.g., nasolabial folds, marionette lines), sunken cheeks, temples, and jawline.

Results appear gradually over 4 to 6 weeks as new collagen is synthesized. The volumizing and rejuvenating effects are long-lasting, typically persisting for 18 to 24 months.

Store in a cool, dry place away from direct sunlight. Once reconstituted, the product should be used within the recommended timeframe according to standard PLLA protocols.

Patients are typically advised to massage the treated area gently for 5 minutes, 5 times a day, for 5 days to ensure even product distribution and prevent the formation of subcutaneous nodules.

Mild swelling, bruising, redness, and tenderness at the injection sites.

It is a PLLA collagen biostimulator for gradual, natural-looking volume restoration, deep wrinkle correction, and long-term collagen regeneration for facial contouring.

Poly-L-Lactic Acid (PLLA), a biodegradable, biocompatible synthetic polymer that stimulates the body's natural collagen production (neocollagenesis).

It requires proper reconstitution with Sterile Water for Injection (SWFI) prior to the procedure to ensure an even suspension of PLLA particles.

Strictly for professional medical use, via deep dermal or subcutaneous injection; do not inject intravascularly or into the superficial epidermis.

• PLLA: Stimulates natural collagen production from within, enhancing volume and visibly reducing wrinkles over time.
• PN (Polynucleotide / Sodium DNA): Supports skin healing, tissue repair, and cell renewal with high biocompatibility.
• Sodium Hyaluronate: Provides intense moisture, aids regeneration, and reinforces the skin barrier function.
• Glutathione & Vitamin C: Protect against oxidative stress, deliver a brightening effect, and help prevent melanogenesis (melanin production inhibition).

• Optimized particle shape reduces the risk of nodules and granulomas, with a consistent particle size of 30–80 µm to help prevent inflammation.
• Manufactured using advanced preserving technology — formulated without parabens, harsh preservatives, or fragrances.

• Biostimulates collagen production and repairs skin tissue
• Restores volume and deeply hydrates from within
• Brightens complexion and reduces fine lines and acne marks
• Improves overall firmness, skin elasticity, and provides a radiant, youthful glow

• After 1st session: Visible improvements in skin texture, hydration, and brightening.
• After subsequent sessions: Cumulative effects on firmness, fine lines, and collagen restoration.

• 1 Add 4–6 cc of sterilized water to the dry pink powder in the vial.
• 2 Shake thoroughly to ensure even distribution of the powder.
• 3 Leave to set for 2–3 minutes before application.

• Protect from direct sunlight and excessive heat.
• Do not freeze.

• Avoid excessive heat exposure and UV until initial swelling has fully resolved.
• Follow standard post-care protocols for injectable treatments.

PDLLA acts as an internal biostimulator, triggering fibroblasts to produce collagen and elastin to rebuild the skin's foundational structure. CMC functions externally to enhance viscosity, ensure stable and uniform delivery of particles, and significantly reduce migration risk.

• 1 BPPT Technology (Biostimulator Particle Processing Technology) — produces uniform microspheres precisely controlled to 20–40 µm, minimizing risks of clumping, blockage, nodules, and granulomas.
• 2 D- & L-Isomer Blend — lower crystallinity with controlled biodegradation for smoother, more predictable results.
• 3 GRAS-Certified U.S. Raw Materials — manufactured to the highest safety standards in a Korean GMP sterile facility.

• Collagen regeneration from within for deep skin enhancement
• Long-lasting volume restoration and structural support
• Improved skin elasticity and overall texture
• Facial contour enhancement and definition

• 1 Mix with sterile distilled water and 1–2% lidocaine. Do not use saline — CMC does not dissolve properly in saline.
• 2 Mix using one of the following methods: electric shaker for 15–20 min, manual shaking for 20–30 min, or a 3-way connector.
• 3 Confirm a fully dissolved gel with no visible particles before use.
• 4 Remove only the external white cap. Do not open the vial body directly to preserve sterility.

• Never open the vial body — preserving sterility requires only the external white cap to be removed.
• Avoid creating air bubbles during the shaking or mixing process.

• Early volume loss (Days 3–5): Normal and expected for PDLLA — volume is restored after 3–4 weeks as collagen production begins.
• Adverse event risk: <0.1% — attributed to refined particle uniformity and CMC stabilization.

• Product cannot be dissolved with saline if removal is required. Use HIFU, ultrasound, or laser modalities instead.