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• Barrier Formation: PN forms a physical barrier on the skin to block environmental stressors and maintain optimal moisture levels.
• Fibroblast Activation: Activates fibroblasts to stimulate collagen synthesis, restoring skin structure and elasticity from within.
• Anti-inflammatory Action: Provides anti-inflammatory support to improve the overall skin environment and support tissue recovery.

• Restores oil-water balance and reduces sebum secretion for improved skin texture
• Replenishes elastic fibers including collagen, enhancing the skin's self-healing capacity
• Promotes wound and scar healing
• Effectively improves dryness, pigmentation, wrinkles, and skin sagging

Provides an extended maintenance and retention period attributed to the long DNA chain structure of the PN, which slows degradation and prolongs efficacy in the skin.

Breaks down within the body at a constant form to provide temporal reduction of facial wrinkles.

High purity formulation that triggers no immune response. Officially classified as a medical device.

• Improvement of skin elasticity, anti-aging, and skin brightening.
• Hydration and moisturization.
• Reduces sebum production and oil secretion.
• Provides a glowing effect and revitalizes collagen.

Forehead lines, glabella frown lines (11's), crow's feet, under eye lines, smile lines, marionette lines (prejowl), and platysmal neck rings.

Store in a cool, dry place away from direct sunlight. Strictly for single-use application; safely discard the syringe and needle after use.

Injection site reactions such as mild swelling, redness, bruising, tenderness, and temporary "embossing" (small bumps at the injection points).

• Apply broad-spectrum sunscreen diligently.
• Avoid direct UV exposure, extreme heat (e.g., saunas, hot tubs), and strenuous workouts for at least 48 hours to prevent infection and prolonged swelling.

• Polynucleotide (PN) 1%: Deeply hydrates the skin, regulates sebum secretion, and softens and brightens skin texture.
• Polydeoxyribonucleotide (PDRN) 1%: Promotes blood circulation, stimulates fibroblast growth to activate collagen and elastin synthesis, and repairs damaged tissues through strong anti-inflammatory effects.

Multi-molecular weight Hyaluronic Acid, Peptide complex, Amino acid blend, and Antioxidants.

Formulated with natural ingredients that have a 97% match to human DNA, effectively preventing allergic and toxic reactions while promoting profound cellular regeneration.

• Intensive Hydration: Restores deep moisture balance.
• Skin Regeneration: Overall skin regeneration, elasticity restoration, and tone enhancement.
• Texture & Clarity: Reduction of fine wrinkles, pore reduction, and alleviation of acne scars.
• Pigmentation: Improvement of melasma and hyperpigmentation.

Microneedling Therapy System (MTS), Mesotherapy (dermal injection), micro-deposit, or grid injection techniques. Efficacy is significantly enhanced when combined with laser treatments or sonophoresis.

Single-use vials. Open and use immediately.

Mild swelling, redness, bruising, and tenderness at the injection site.

• Apply sunscreen diligently.
• Avoid direct sunlight, excessive heat (e.g., saunas), and harsh environments for a few days post-treatment.

It is a cellular skin booster for intensive hydration, skin regeneration and elasticity, fine wrinkle and pore reduction, acne scar improvement, and pigmentation correction.

Polynucleotide (PN) 1% and Polydeoxyribonucleotide (PDRN) 1%, supported by multi-molecular weight Hyaluronic Acid, a peptide complex, amino acids, and antioxidants.

There is immediate hydration and improvement upon administration, with deep cellular regeneration effects lasting up to 12 months, over a course of 3 to 6 sessions at 2 to 4-week intervals.

Strictly for professional medical and aesthetic use via MTS, mesotherapy, micro-deposit, or grid injection; intravascular injection is strictly prohibited.

It is manufactured by Cosmoderma, Inc.

Polynucleotide (derived from salmon DNA) regenerates tissue and improves skin density in the dermis, while Hyaluronic Acid provides deep hydration. Glutathione acts as an antioxidant to brighten the skin, and Collagen Peptides stimulate elasticity.

Targeted eye rejuvenation including dark circle reduction and brightening. It provides fine wrinkle correction (Crow's feet), strengthens the skin barrier, and offers deep hydration with improved elasticity.

Under-eye area (Tear troughs), Crow's feet, Neckline, Back of hands, and thin wrinkles on the face.

Ready-to-use pre-filled syringe (No reconstitution required).

Store away from direct sunlight. The product is for single-use only.

• Temporary redness at the injection site
• Swelling or bruising
• Tenderness

• Avoid heavy makeup for a few hours post-injection
• Avoid touching the treated area

It is used for targeted eye rejuvenation, including dark circle reduction, brightening, fine wrinkle correction (Crow's feet), skin barrier strengthening, and deep hydration with improved elasticity.

Its primary active ingredients are Polynucleotide (PN) 1% (derived from salmon DNA) and Sodium Hyaluronate (HA) 0.5%.

It is administered by injection (mesotherapy / intradermal injection) using a 32G or 33G (4mm length) needle, with 3 sessions recommended at 20–30 day intervals.

It is for professional use only and should be administered by a qualified practitioner.

REJUBEAU Eye Deal is manufactured by TRACLE INC.

• Sodium Hyaluronate (HA): 1.0% (10mg/mL) – Non-crosslinked, high-purity.
• Polynucleotide (PN): 0.5% – DNA-derived agent for tissue regeneration.

• Glutathione: Brightening and antioxidant protection.
• Peptide Complex: Acetyl Hexapeptide-8, Palmitoyl Tripeptide-5, 4, 7, Collagen Peptides.
• Adenosine: Functional ingredient for wrinkle improvement.

This product combines intense hydration with tissue regeneration. HA draws moisture into the dermis to restore volume, while PN (Salmon DNA) activates self-regeneration power. Simultaneously, Glutathione inhibits melanin for brightening, and the Peptide complex supports the formula's fine-line care.

• Intense and deep skin hydration (Hydro-lifting effect)
• Skin barrier strengthening and tissue regeneration
• Skin tone improvement and brightening (Radiance/Glow)
• Reduction of fine lines and wrinkles (Anti-aging)
• Pore tightening and texture refinement

The product comes in a ready-to-use pre-filled syringe; no dilution is required.

• Keep away from direct sunlight and heat sources.
• Do not freeze.
• Single-use only; discard any remaining solution after opening.

• Temporary redness or swelling
• Bruising or needle marks at injection sites
• Symptoms usually subside within 1–3 days

• Avoid heavy makeup for 24 hours.
• Avoid saunas, steam rooms, and strenuous exercise for a few days after treatment.

It is used for intense deep skin hydration (hydro-lifting), skin barrier strengthening and tissue regeneration, brightening, reduction of fine lines and wrinkles, and pore tightening with texture refinement.

Its primary active ingredients are Sodium Hyaluronate (HA) 1.0% (10mg/mL, non-crosslinked) and Polynucleotide (PN) 0.5% (salmon DNA-derived).

A course of 3–5 sessions spaced 3–4 weeks apart is recommended, with maintenance every 3–6 months.

It is a medical device intended for professional use only and should be administered by a qualified practitioner.

REJUBEAU Aqua Bomb is manufactured by TRACLE Inc.

• PLLA: Stimulates natural collagen production from within, enhancing volume and visibly reducing wrinkles over time.
• PN (Polynucleotide / Sodium DNA): Supports skin healing, tissue repair, and cell renewal with high biocompatibility.
• Sodium Hyaluronate: Provides intense moisture, aids regeneration, and reinforces the skin barrier function.
• Glutathione & Vitamin C: Protect against oxidative stress, deliver a brightening effect, and help prevent melanogenesis (melanin production inhibition).

• Optimized particle shape reduces the risk of nodules and granulomas, with a consistent particle size of 30–80 µm to help prevent inflammation.
• Manufactured using advanced preserving technology — formulated without parabens, harsh preservatives, or fragrances.

• Biostimulates collagen production and repairs skin tissue
• Restores volume and deeply hydrates from within
• Brightens complexion and reduces fine lines and acne marks
• Improves overall firmness, skin elasticity, and provides a radiant, youthful glow

• After 1st session: Visible improvements in skin texture, hydration, and brightening.
• After subsequent sessions: Cumulative effects on firmness, fine lines, and collagen restoration.

• 1 Add 4–6 cc of sterilized water to the dry pink powder in the vial.
• 2 Shake thoroughly to ensure even distribution of the powder.
• 3 Leave to set for 2–3 minutes before application.

• Protect from direct sunlight and excessive heat.
• Do not freeze.

• Avoid excessive heat exposure and UV until initial swelling has fully resolved.
• Follow standard post-care protocols for injectable treatments.

Spider silk proteins create a mesh-like structure for immediate lifting and tightening. Simultaneously, PN stimulates tissue regeneration to thicken the dermis, while HA and Urea provide deep hydration to plump fine lines.

• Periorbital Rejuvenation: Specifically targets the delicate eye area to thicken thin skin.
• Wrinkle Reduction: Smoothes crow's feet and fine lines.
• Lifting & Elasticity: Improves skin tension and firmness (Spider Web Effect).
• Dark Circle Improvement: Brightens the under-eye area by increasing skin density.

Ready-to-use pre-filled syringe. No mixing required.

Specialized for the thin skin around the eyes using Spider Polypeptide for lifting without excessive volume, avoiding puffiness. Ideal for patients concerned with crepey skin and dark circles.

Store in a cool, dry place away from direct sunlight. Do not freeze. Single-use only.

• Mild swelling (edema) or bruising (ecchymosis) around the eyes (subsides in 3–5 days).
• Injection bumps (papules) may last 1–2 days.

• Avoid rubbing the eyes.
• Avoid saunas and heavy exercise for 3–5 days.

It is used for periorbital rejuvenation, including wrinkle reduction (crow's feet and fine lines), lifting and elasticity, and dark circle improvement around the delicate eye area.

Its primary active ingredients are Spider Polypeptide, Polynucleotide (PN), and non-crosslinked HA, supported by Tetrapeptide-44 and Urea.

Visible results appear in 1–2 weeks and effects last 6–9 months. A course of 3 sessions spaced 3–4 weeks apart is recommended.

It is for professional use only and should be administered by a qualified practitioner.

SPIDER AQUA EYE BOOSTER is manufactured by BDK Co., Ltd.

• Sodium Hyaluronate (H-HA + L-HA): Dual molecular weight HA delivers intensive hydration and elasticity improvement across multiple skin layers simultaneously.
• Polynucleotide: Supports skin regeneration at a cellular level and stimulates natural collagen synthesis.
• Tranexamic Acid & Niacinamide: Reduce pigmentation, strengthen the skin barrier, and promote a brighter, more even complexion.
• Glutathione: Provides powerful antioxidant protection to defend against free radical damage and dullness.
• Recombinant Collagen: Enhances dermal firmness and structural integrity. Active ingredients are delivered directly into the dermis to revitalize the complexion.

• Intense moisture boost and improved skin elasticity
• Enhanced natural glow and skin brightness
• Improved skin clarity and even skin tone
• Supports skin regeneration and firming

• Protect from direct light.
• Do not freeze.
• Sterile product — do not reuse syringes.

• Avoid intense heat and strenuous exercise for a few days following treatment.

PLA (Poly-L-Lactic Acid), PN (Polynucleotides), NAD-(NMN), HA (Hyaluronic Acid), Niacinamide, Vitamin B2, and Succinic Acid.

A multi-modal biostimulator that shifts beyond simple filling by delivering instant improvements in skin quality alongside long-lasting structural remodeling and cellular repair.

• Immediate deep hydration and radiant glow.
• Long-term structural volumization and increased dermal density.
• Skin regeneration and enhanced cellular energy.
• Brightening and antioxidant protection.

• Face: Neck wrinkles, forehead lines, frown lines, crow's feet, and marionette lines.
• Eyes: Dark circles, eye wrinkles, and eye bags.
• Body: Wrinkle care, tightening, cellulite, stretch marks, and brightening for areas like hands, knees, elbows, and armpits.

Onset: Immediate hydration and optical smoothness from HA.
Duration: Gradual accumulation of new collagen and elastin over weeks to months, providing long-term volumization.

Typically 24-36 months from the manufacturing date. Once reconstituted, the solution should be used immediately.

• Side Effects: Mild swelling, redness, bruising, or tenderness at the application sites.
• Post-Care: Apply sunscreen diligently. Avoid excessive heat exposure (e.g., saunas) and strenuous physical activity for a few days post-treatment.

It is a multi-modal biostimulator for immediate hydration and glow, long-term structural volumization, skin regeneration, and brightening across the face, eyes, and body.

PLA (Poly-L-Lactic Acid), PN (Polynucleotides), NAD-(NMN), HA (Hyaluronic Acid), Niacinamide, Vitamin B2, and Succinic Acid.

Shake the vial by hand for 1 minute to reconstitute the lyophilized powder; once reconstituted, the solution should be used immediately.

Strictly for professional medical and aesthetic use, administered into the dermal/subcutaneous layer; do not inject intravascularly.

Polynucleotide (PN), derived from salmon DNA, acts as a tissue regeneration activator. It stimulates the synthesis of collagen and elastin in the dermis (Extra Cellular Matrix restoration) and promotes angiogenesis (formation of new blood vessels) to improve skin density and thickness.

Provides comprehensive skin regeneration and wound healing by accelerating the repair of damaged skin. It improves elasticity and reduces fine lines for anti-aging, smooths skin texture while reducing pore size, and strengthens the skin barrier against environmental stress.

Full Face (General skin rejuvenation), Neck wrinkles, areas with acne scars or enlarged pores, and thin/damaged skin requiring regeneration.

Ready-to-use pre-filled syringe. No dilution required.

Store away from direct sunlight. Do not freeze. Single-use only; discard any remaining solution.

• "Embossing" (small raised bumps) - typically subsides within 24–48 hours
• Mild redness (Erythema), swelling, or bruising
• Mild pain or tenderness

• Avoid makeup for at least 6–12 hours
• Avoid saunas, steam rooms, heavy exercise, and alcohol for 3–7 days
• Apply sunscreen and moisturizer regularly

It provides comprehensive skin regeneration and wound healing, improving elasticity, reducing fine lines for anti-aging, smoothing skin texture while reducing pore size, and strengthening the skin barrier.

Its primary active ingredient is Polynucleotide (PN) 2% (20mg/ml), derived from salmon DNA.

Visible improvements typically appear 1–2 weeks after the first session, with effects lasting 6–12 months. A course of 3 to 4 sessions at 2–3 week intervals is recommended.

It is for professional use only and should be administered by licensed medical practitioners.

REJUBEAU PN Healer is manufactured by TRACLE INC.