Beauty tips

If you are interested in Korean medical aesthetics, you have likely heard of the "Salmon Injection." But when you look closer at the ingredients, you often see two confusing acronyms: PDRN and PN. Are they the same thing? Not exactly. While they originate from the same source, their medical applications and cosmetic effects are distinct. Here is a comprehensive breakdown of these two powerful regenerative ingredients to help you choose the right product for your customers.     1. The Common Origin: Salmon DNA Both PDRN and PN are DNA fragments derived from the sperm of Salmon (Oncorhynchus keta) or Trout. Why Salmon? Salmon DNA base composition is highly similar to human DNA (approximately 95% match). This ensures high biocompatibility, meaning there is very little risk of immune rejection or side effects when injected into the human body.     2. PDRN (Polydeoxyribonucleotide): The Rapid Healer Think of PDRN as "Medicine for Wounds.” Structure: PDRN consists of shorter DNA chains with a lower molecular weight. Mechanism: It works on the adenosine A2A receptors in the body to trigger a rapid anti-inflammatory response and promote angiogenesis (the formation of new blood vessels). Key Benefits: Tissue Repair: Accelerates the healing of wounds, ulcers, and scars. Anti-Inflammation: Reduces redness and swelling significantly. Scalp Care: Often used in mesotherapy for hair loss to improve blood circulation in the scalp. Texture: It is a liquid solution (water-like viscosity), making it easy to absorb but less suitable for building structure in the skin.     3. PN (Polynucleotide): The Skin Architect Think of PN as "Construction Material for the Skin.” Structure: PN is a longer, more complex DNA chain with a higher molecular weight than PDRN. It is essentially a more concentrated and viscous form of PDRN. Mechanism: Because it is heavier and more viscous, PN doesn't just heal; it acts as a 3D scaffold within the dermis. It physically supports the skin structure while slowly breaking down to fuel skin regeneration. Key Benefits: ECM Restoration: It regenerates the Extracellular Matrix (ECM), increasing skin thickness and density. Elasticity & Hydration: It restores the oil-water balance and improves skin elasticity (famous for the Rejuran Healer effect). Long-lasting: Due to its larger size, it stays in the skin longer than PDRN, providing sustained regenerative effects.      4. Key Differences at a Glance Feature PDRN PN Full Name Polydeoxyribonucleotide Polynucleotide Molecular Weight Low (Short DNA chains) High (Long DNA chains) Viscosity Low (Liquid) High (Gel-like) Primary Goal Healing & Anti-inflammation Regeneration & Support Main Use Wound healing, Hair mesotherapy Anti-aging, Skin barrier repair, Fine lines     The choice between PDRN and PN depends on the goal. If the objective is to quickly heal damaged tissue, treat inflammation, or improve scalp health, PDRN is the effective choice. However, if the goal is aesthetic anti-aging—improving skin elasticity, reducing fine lines, and thickening a thin skin barrier—PN is the superior option. In the current 2025 market, PN (found in products like Rejuran) is the dominant standard for "Skin Boosters," while PDRN retains its value in therapeutic and mesotherapy sectors.