COLLECTION

Skin Recovery and Regeneration

Revitalize your skin with our collection of K-Derma products for recovery and regeneration. These powerful solutions help repair damaged skin, promote cell turnover, and restore a youthful appearance.

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Authentic POLYDIO Polydioxanone PDO 300mg Collagen Stimulator Korea Wholesale

POLYDIO - Polydioxanone (PDO 300mg × 1 Vial)

$77.00

POLYDIO PDO Dermal Filler - Product Details

K-one Pharma Dermal Filler 300mg

POLYDIO

PDO 300mg x 1 Vial

Advanced polydioxanone-based collagen stimulator for long-lasting skin rejuvenation and natural volume restoration.

Biostimulatory filler with 1-2 years lasting effect through natural collagen regeneration

Main Product Image Placeholder

Product Overview

POLYDIO is a revolutionary PDO-based dermal filler that stimulates natural collagen production for sustained aesthetic improvements.

Product Packaging

Product Vial and Packaging

Single vial containing 300mg powder for reconstitution

Mechanism of Action

Collagen Regeneration Process

Visual demonstration of PDO microsphere collagen stimulation

Treatment Applications

Treatment Areas Diagram

Facial areas suitable for POLYDIO application

Composition & Components

Active Ingredients

Polydioxanone (PDO) Carboxymethyl Cellulose (CMC)

Concentration & Ratio

PDO 150mg CMC 150mg Total 300mg

Component Functions

PDO acts as a biocompatible and absorbable synthetic polymer that stimulates natural collagen production. CMC serves as a carrier gel to facilitate proper injection and distribution.

Particle Specifications

Uniform spherical PDO microspheres with particle size range of 10-60μm for optimal tissue integration and collagen stimulation.

PDO Microsphere Structure

Expected Benefits & Functions

Collagen Stimulation

Promotes natural collagen regeneration and skin tissue renewal

Neocollagenesis Fibroblast Activation

Skin Improvement

Enhanced skin elasticity, firmness, and overall texture quality

Elasticity Firmness

Anti-Aging Effects

Reduction of fine lines, wrinkles, and improvement in skin tone

Wrinkle Reduction Pore Refinement

Before Treatment Image

After Treatment Results

Long-term aesthetic benefits are achieved through gradual biodegradation of PDO microspheres over approximately 1 year, during which continuous collagen and elastin production occurs.

Key Benefits Summary

Collagen regeneration and stimulation for natural skin renewal
Improvement of fine lines and wrinkles through tissue remodeling
Enhanced skin elasticity and firmness with lasting results
Pore reduction and overall skin tone improvement
Natural volume restoration without synthetic fillers
Long-lasting effects maintained for 1-2 years post-treatment

Application Protocol

Product Reconstitution

Reconstitute 300mg powder with sterile water for injection using 18G needle

Preparation

Optional lidocaine addition for patient comfort during injection procedure

Injection Technique

Inject into dermal and subcutaneous layers using 26G cannula

Post-Treatment

Monitor for optimal integration and collagen stimulation response

Injection Parameters

Target Layer: Between dermis and subcutaneous area
Recommended Needle: 26G Cannula for injection
Reconstitution: 18G needle for preparation
Application: Single-use vial, immediate use after preparation

Treatment Areas

All facial areas including fine lines and wrinkles
Pore refinement and skin texture improvement
Skin hydration and elasticity enhancement
Overall facial skin tone and volume restoration

Injection Technique Visual Guide

Treatment cycle provides long-lasting effects with results maintained for 1-2 years due to gradual biodegradation and continuous neocollagenesis.

Technical Specifications

300mg

Total Product Weight

10-60μm

Particle Size Range

1-2years

Effect Duration

Component	Concentration	Function	Properties
Polydioxanone (PDO)	150mg	Collagen Stimulator	Biocompatible, Absorbable
Carboxymethyl Cellulose (CMC)	150mg	Carrier Gel	Injectable Suspension
Total Content	300mg	Biostimulator	Powder for Reconstitution

Storage & Handling

Store at room temperature (1-30°C). Protect from direct sunlight. Single-use vial for immediate application after reconstitution.

Biodegradation

PDO degrades into water and carbon dioxide, which are neutral to the body, ensuring safe biocompatibility.

Mechanism of Action

Collagen Production Timeline

Biostimulation Process

PDO microspheres activate fibroblasts upon injection
Gradual biodegradation stimulates collagen synthesis
Continuous neocollagenesis over 12-month period
Enhanced elastin production for improved skin elasticity

The spherical PDO particles integrate with dermal tissue, providing sustained collagen stimulation as they naturally biodegrade.

Safety Information

Professional Use Only — This product is intended for use by qualified medical professionals in appropriate clinical settings.

Contraindications & Precautions

Do not use on inflamed or infected areas
Ensure proper reconstitution before injection
Single-use vial - do not reuse or store after opening
Follow aseptic technique throughout procedure

Post-Treatment Guidelines

Monitor injection sites for normal healing response
Advise patients on appropriate post-care protocols
Schedule follow-up appointments as clinically indicated

Frequently Asked Questions

The aesthetic effects of POLYDIO are maintained for approximately 1-2 years. The PDO microspheres gradually biodegrade over about 1 year, during which they continuously stimulate collagen and elastin production.

Unlike traditional hyaluronic acid fillers, POLYDIO is a biostimulator that works by stimulating the body's natural collagen production rather than simply adding volume. This results in more natural, long-lasting improvements.

Store at room temperature (1-30°C) away from direct sunlight. The powder must be reconstituted with sterile water for injection immediately before use. Each vial is for single use only.

POLYDIO can be used on all facial areas for improvement of fine lines, wrinkles, pores, skin hydration, elasticity, and overall tone. It's injected between the dermis and subcutaneous layers.

Technical Documentation

Product Manual

Clinical Guidelines

Comprehensive injection protocols and safety guidelines

Certificate Documents

Quality Assurance

Manufacturing standards and quality control documentation

Research Data

Clinical Studies

Scientific evidence supporting efficacy and safety profile

AESTHE FILL 200mg

$340.00

AESTHE FILL 200mg Product Description

AESTHE FILL 200mg

Powerful Collagen Stimulator (1 Vial)

AESTHE FILL 200mg

1 Vial - 200mg Lyophilized Powder

Advanced PDLLA Biostimulator for Natural Collagen Regeneration

Revolutionary poly-D,L-lactic acid formula for long-lasting facial volume restoration and skin rejuvenation

PDLLA Filler Biostimulator Collagen Stimulator

Long-Lasting Results

Up to 2 years or more of effectiveness

Natural collagen regeneration provides gradual, long-lasting volumizing effects that continue to improve over time

Biocompatible

Safe biodegradable polymer technology

PDLLA technology safely stimulates neocollagenesis while gradually biodegrading in the body

Versatile Application

Multiple treatment areas and customizable concentration

From fine lines to deep volume loss, concentration can be customized during reconstitution for optimal results

Key Ingredients & Technical Features

Poly-D,L-Lactic Acid (PDLLA)

200mg per vial

Primary biocompatible and biodegradable polymer that stimulates natural collagen production. Forms porous microsphere structure to promote neocollagenesis and provide long-lasting volumizing effects.

Cross-linking Method

Not applicable for PDLLA biostimulator. Works by forming a porous microsphere structure that stimulates neocollagenesis rather than traditional cross-linking methods.

Gel Structure

Lyophilized powder reconstituted into suspension. PDLLA particles maintain porous, microsphere structure for optimal biocompatibility and effectiveness.

Formulation Type

Single-use vial containing 200mg powder for reconstitution with sterile water. Does not contain Lidocaine for maximum compatibility.

PDLLA Microsphere Structure - Technical illustration showing porous structure and collagen stimulation mechanism

Benefits & Efficacy

Volume Restoration

Facial Volume Restoration

Effectively restores lost facial volume in cheeks and temples through natural collagen regeneration
Deep Wrinkle Improvement

Significantly improves nasolabial folds and marionette lines with long-lasting results
Facial Contouring

Enhanced contouring of face, jawline, and chin for improved facial definition

Skin Quality Enhancement

Skin Tightening & Lifting

Natural skin tightening effect through collagen stimulation for improved facial contours
Texture & Firmness

Enhanced skin texture, firmness, and elasticity through neocollagenesis process
Natural Regeneration

Biostimulator naturally regenerates collagen to address skin issues caused by collagen depletion

Long-lasting Natural Results Collagen Boost Gradual Improvement

Before and After Comparison - Visual evidence of volume restoration and wrinkle improvement results

Treatment Protocol & Application Guide

Injection Layer & Depth

Deep dermis or subcutaneous layer injection recommended. Injection depth can be varied based on specific treatment area and desired effect for optimal results.

Needle Specifications

Sterile 25G or 26G cannula needle recommended for injection. Proper needle selection ensures optimal product delivery and patient comfort.

Treatment Cycle

Complete treatment of 1-3 sessions recommended for optimal results. Maintain 4-6 week intervals between each session for proper tissue response.

Reconstitution Guidelines

Reconstitute with sterile water to form suspension for injection. Concentration can be customized during reconstitution to suit different treatment areas.

Volume Strategy Applications

Thick suspension for temples, malar region, nasolabial folds, jawline, and chin. Inject into deep dermis or subcutaneous layer using 25G-26G cannula.

Fine Line Strategy Applications

Thin suspension for eye area, forehead, and neck lines. Inject into superficial dermis with finer gauge for subtle improvements.

Single-Use Protocol

Product is for single-use after reconstitution. Must be used immediately after preparation to maintain sterility and effectiveness.

Treatment Application Guide - Visual demonstration of proper injection techniques and depth for different areas

Treatment Strategy Comparison

Treatment Strategy	Viscosity	Treatment Area	Injection Layer	Needle Gauge
Shallow Wrinkles	Thin suspension	Eye area, forehead, neck lines	Superficial dermis	Fine gauge recommended
Deep Wrinkles & Volume	Thick suspension	Temples, malar region, nasolabial folds, jawline, chin	Deep dermis / Sub-Q	25G to 26G cannula

Volume Strategy (Thick Suspension)

Target Areas

Cheeks, temples, nasolabial folds, jawline, chin for significant volume restoration
Duration

Results can last up to 2 years or more with gradual, long-lasting volumizing effect
Application Method

Deep dermis or subcutaneous injection using cannula for immediate filling and collagen stimulation

Fine Line Strategy (Thin Suspension)

Target Areas

Fine lines on face, neck, and hands for general skin rejuvenation
Duration

Long-lasting effects building up over several months through collagen stimulation
Application Method

Superficial dermis injection focusing on skin quality and texture improvement

3D Facial Mapping for Volume Restoration - Before and after visualization showing treatment areas and results

Safety Information & Precautions

Important Precautions

Avoid strenuous activity, saunas, and direct sun exposure for 48 hours post-treatment. Do not receive injections if pregnant, breastfeeding, or if there is an active infection or inflammation at the injection site.

Storage Requirements

Store product at stable temperature away from direct sunlight. Product is for single-use after reconstitution and should be used immediately after preparation to maintain sterility and effectiveness.

Post-Treatment Care

Follow recommended aftercare procedures for optimal results. Avoid excessive facial movements and maintain proper hygiene at injection sites.

Contraindications

Not suitable for pregnant or breastfeeding women. Avoid treatment in areas with active infection, inflammation, or compromised skin integrity.

Professional Administration

Treatment should only be performed by qualified medical professionals with appropriate training in dermal filler and biostimulator injection techniques.

Precautions and Aftercare Infographic - Visual guide showing post-treatment care instructions and safety guidelines

Product Specifications

Specification	Details	Notes
Active Ingredient	Poly-D,L-Lactic Acid (PDLLA)	Biocompatible polymer
Concentration	200mg per vial	Lyophilized powder
Package Contents	1 vial	Single-use application
Lidocaine Content	Lidocaine-free	Enhanced compatibility
Reconstitution	Sterile water	Forms suspension
Recommended Needle	25G-26G cannula	Sterile application

Storage Conditions

Store at stable temperature away from direct sunlight. Keep in original packaging until use to maintain product integrity.

Shelf Life

Product maintains effectiveness when stored under recommended conditions. Check expiration date before use and follow storage guidelines.

Quality Assurance

Manufactured following strict quality control standards. Each batch undergoes comprehensive testing for safety and effectiveness.

Key Performance Indicators:
Duration: Up to 2+ Years
Sessions: 1-3 Treatments
Interval: 4-6 Weeks

Product Specifications and Quality Documentation - Technical data sheets and manufacturing standards

PDLLA Filler Polylactic Acid Collagen Stimulator Facial Volume

Wrinkle Improvement Long-lasting Filler Biostimulator Facial Contouring

Skin Rejuvenation Vial Type Authentic Derma