Skin Recovery and Regeneration

• 1 Immediate (CMC Phase): Immediately after injection, the dermis layer is filled with CMC gel, providing instant volume and supporting the surrounding tissue.
• 2 Long-term (PLA Phase): As the CMC gel is gradually absorbed and dissolved, the PLA microspheres remain in place and stimulate cells to produce new collagen — delivering natural wrinkle improvement from the inside out.

• HMT (Homologous Microsphere Technology): Creates perfectly spherical and uniform PLA particles precisely sized at 30–50 µm for consistent, predictable results.
• High Molecular Weight: 190,000–250,000 Da — ensures structural integrity and sustained collagen stimulation over time.
• Eco-Friendly & Biodegradable: No BDDE residue. PLA material fully degrades within 1–2 years.

• Acts as a natural collagen stimulator to dramatically restore volume
• Improves deep wrinkles and gradually rejuvenates overall skin texture
• Delivers dual-phase action: immediate volumizing followed by sustained collagen regeneration

• 1 Add 1.4 mL of WFI (Water For Injection) to the vial.
• 2 Allow to dissolve at room temperature. Standard dissolution time is approximately 1 hour (full dissolution confirmed within 60–90 minutes).
• 3 Confirm beads are completely dissolved before proceeding to injection to ensure even particle suspension.

• Do not freeze.
• Must be properly reconstituted prior to injection to ensure even particle suspension.

• PLLA: Stimulates natural collagen production from within, enhancing volume and visibly reducing wrinkles over time.
• PN (Polynucleotide / Sodium DNA): Supports skin healing, tissue repair, and cell renewal with high biocompatibility.
• Sodium Hyaluronate: Provides intense moisture, aids regeneration, and reinforces the skin barrier function.
• Glutathione & Vitamin C: Protect against oxidative stress, deliver a brightening effect, and help prevent melanogenesis (melanin production inhibition).

• Optimized particle shape reduces the risk of nodules and granulomas, with a consistent particle size of 30–80 µm to help prevent inflammation.
• Manufactured using advanced preserving technology — formulated without parabens, harsh preservatives, or fragrances.

• Biostimulates collagen production and repairs skin tissue
• Restores volume and deeply hydrates from within
• Brightens complexion and reduces fine lines and acne marks
• Improves overall firmness, skin elasticity, and provides a radiant, youthful glow

• After 1st session: Visible improvements in skin texture, hydration, and brightening.
• After subsequent sessions: Cumulative effects on firmness, fine lines, and collagen restoration.

• 1 Add 4–6 cc of sterilized water to the dry pink powder in the vial.
• 2 Shake thoroughly to ensure even distribution of the powder.
• 3 Leave to set for 2–3 minutes before application.

• Protect from direct sunlight and excessive heat.
• Do not freeze.

• Avoid excessive heat exposure and UV until initial swelling has fully resolved.
• Follow standard post-care protocols for injectable treatments.

PLLA microparticles stimulate the body's natural collagen production (neocollagenesis) by activating fibroblasts. As the PLLA is gradually absorbed and metabolized by the body, the newly formed collagen restores lost facial volume and improves overall skin elasticity.

Composed of a biodegradable and biocompatible synthetic polymer designed to act as a biostimulator rather than a traditional volumizing filler.

• Gradual and natural-looking volume restoration.
• Deep wrinkle correction.
• Long-term collagen regeneration.
• Improvement of overall skin tone and texture.

Facial contouring, deep wrinkles (e.g., nasolabial folds, marionette lines), sunken cheeks, temples, and jawline.

Results appear gradually over 4 to 6 weeks as new collagen is synthesized. The volumizing and rejuvenating effects are long-lasting, typically persisting for 18 to 24 months.

Store in a cool, dry place away from direct sunlight. Once reconstituted, the product should be used within the recommended timeframe according to standard PLLA protocols.

Patients are typically advised to massage the treated area gently for 5 minutes, 5 times a day, for 5 days to ensure even product distribution and prevent the formation of subcutaneous nodules.

Mild swelling, bruising, redness, and tenderness at the injection sites.

It is a PLLA collagen biostimulator for gradual, natural-looking volume restoration, deep wrinkle correction, and long-term collagen regeneration for facial contouring.

Poly-L-Lactic Acid (PLLA), a biodegradable, biocompatible synthetic polymer that stimulates the body's natural collagen production (neocollagenesis).

It requires proper reconstitution with Sterile Water for Injection (SWFI) prior to the procedure to ensure an even suspension of PLLA particles.

Strictly for professional medical use, via deep dermal or subcutaneous injection; do not inject intravascularly or into the superficial epidermis.

High-purity HA attracts water molecules to the dermis, restoring moisture balance immediately while stimulating fibroblasts to promote endogenous collagen synthesis.

• Intensive Moisturizing: Restores dry and dehydrated skin (Hydro-lifting).
• Skin Rejuvenation: Improves overall skin radiance and brightness (Glow effect).
• Texture Improvement: Tightens pores and smoothes fine lines/wrinkles.
• Elasticity Restoration: Enhances skin firmness through collagen stimulation.

Supplied as ready-to-use pre-filled syringes. No mixing required.

Store away from direct sunlight. Do not freeze. Do not use if the package is damaged.

• Mild redness (erythema) or swelling
• Bruising or tenderness at the injection site
• Symptoms usually resolve within 1–3 days

• Avoid heavy makeup for at least 24 hours.
• Avoid saunas, steam rooms, and excessive heat for 1 week.
• Apply sunscreen diligently.

It is used for intensive moisturizing (hydro-lifting), skin rejuvenation and radiance, texture improvement with pore tightening and fine-line smoothing, and elasticity restoration through collagen stimulation.

Its primary active ingredient is Hyaluronic Acid (HA) 15mg/mL (1.5%), buffered with Phosphate Buffered Saline (PBS) pH 7.0.

Visible improvement appears in 1–2 weeks and effects last 3–6 months. A course of 3–4 sessions at 2–3 week intervals is recommended.

It is a medical device for use by licensed practitioners only and should be administered by a qualified professional.

REGENOVUE Aqua Shine is manufactured by NeoGenesis Co., Ltd.

• Brightening and whitening — inhibits melanin production for a more even, radiant skin tone
• Deep moisturizing and skin barrier reinforcement
• Wrinkle improvement and skin regeneration
• Strong antioxidant defense against environmental stressors
• General facial brightening, moisturizing, and anti-wrinkle skin conditioning

Apply topically to the facial skin. Effective as a standalone topical treatment — no special MTS (microneedling) procedure is required. Microneedling may optionally be paired for enhanced product absorption at the practitioner's discretion.

• Hyaluronic Acid: Provides intense skin hydration and a sustained moisturizing effect throughout the dermis.
• Glutathione & Coenzymes: Deliver strong antioxidant action and a visible whitening effect by inhibiting melanin production.
• Stem Cells & Exosomes (500 million particles): Exert an excellent effect on skin regeneration and strengthen the skin barrier at a cellular level.
• Amino Acids: Stimulate collagen production to provide firm elasticity and improved skin structure.
• Minerals: Activate cellular metabolism to support overall skin vitality and recovery.

• Revitalizes dull skin and provides deep, lasting hydration
• Strengthens the skin barrier and promotes rapid cell regeneration
• Enhances skin elasticity and firmness
• Delivers strong whitening and antioxidant protection
• Effectively repairs damaged cells and accelerates skin recovery

• Protect from direct sunlight.
• Do not freeze.

• 1 Avoid intense heat sources — saunas and prolonged direct sun exposure — for 24–48 hours post-treatment.
• 2 Avoid strenuous exercise for 24–48 hours post-treatment.

• Barrier Formation: PN forms a physical barrier on the skin to block environmental stressors and maintain optimal moisture levels.
• Fibroblast Activation: Activates fibroblasts to stimulate collagen synthesis, restoring skin structure and elasticity from within.
• Anti-inflammatory Action: Provides anti-inflammatory support to improve the overall skin environment and support tissue recovery.

• Restores oil-water balance and reduces sebum secretion for improved skin texture
• Replenishes elastic fibers including collagen, enhancing the skin's self-healing capacity
• Promotes wound and scar healing
• Effectively improves dryness, pigmentation, wrinkles, and skin sagging

Provides an extended maintenance and retention period attributed to the long DNA chain structure of the PN, which slows degradation and prolongs efficacy in the skin.

• Polynucleotide (PN) 1%: Deeply hydrates the skin, regulates sebum secretion, and softens and brightens skin texture.
• Polydeoxyribonucleotide (PDRN) 1%: Promotes blood circulation, stimulates fibroblast growth to activate collagen and elastin synthesis, and repairs damaged tissues through strong anti-inflammatory effects.

Multi-molecular weight Hyaluronic Acid, Peptide complex, Amino acid blend, and Antioxidants.

Formulated with natural ingredients that have a 97% match to human DNA, effectively preventing allergic and toxic reactions while promoting profound cellular regeneration.

• Intensive Hydration: Restores deep moisture balance.
• Skin Regeneration: Overall skin regeneration, elasticity restoration, and tone enhancement.
• Texture & Clarity: Reduction of fine wrinkles, pore reduction, and alleviation of acne scars.
• Pigmentation: Improvement of melasma and hyperpigmentation.

Microneedling Therapy System (MTS), Mesotherapy (dermal injection), micro-deposit, or grid injection techniques. Efficacy is significantly enhanced when combined with laser treatments or sonophoresis.

Single-use vials. Open and use immediately.

Mild swelling, redness, bruising, and tenderness at the injection site.

• Apply sunscreen diligently.
• Avoid direct sunlight, excessive heat (e.g., saunas), and harsh environments for a few days post-treatment.

It is a cellular skin booster for intensive hydration, skin regeneration and elasticity, fine wrinkle and pore reduction, acne scar improvement, and pigmentation correction.

Polynucleotide (PN) 1% and Polydeoxyribonucleotide (PDRN) 1%, supported by multi-molecular weight Hyaluronic Acid, a peptide complex, amino acids, and antioxidants.

There is immediate hydration and improvement upon administration, with deep cellular regeneration effects lasting up to 12 months, over a course of 3 to 6 sessions at 2 to 4-week intervals.

Strictly for professional medical and aesthetic use via MTS, mesotherapy, micro-deposit, or grid injection; intravascular injection is strictly prohibited.

It is manufactured by Cosmoderma, Inc.

• H-HA (High molecular weight HA): 67.5mg
• L-HA (Low molecular weight HA): 67.5mg
• PDRN (Polydeoxyribonucleotide): 5mg
• PN (Polynucleotide): 5mg

H-HA & L-HA provide intense moisture, enhance skin elasticity, and maintain long-lasting volume. PDRN & PN promote cell regeneration, offer anti-inflammatory effects, enhance wound healing, and repair broken collagen and elastin fibers.

• Hydration & Volume: Intense moisturizing and long-lasting volume support.
• Rejuvenation: Wrinkle reduction, collagen & elastin regeneration.
• Healing & Tone: Anti-inflammatory wound healing, whitening, and scar/acne improvement.

Cycle: 3 treatments at 2-week intervals.
Onset: Rapid onset with PDRN/PN action visible in 1-2 weeks.
Duration: Overall effect lasts 4 to 8 months.

Single-use vial. Discard any remaining solution after opening.

• Common Effects: Mild swelling, redness, bruising, tenderness, or temporary papules (bumps) at injection sites.
• Post-Care: Avoid heavy makeup for 24 hours. Avoid extreme heat (saunas, hot baths) and strenuous exercise for a few days. Apply sunscreen regularly.

It is a skin booster for deep hydration, skin texture improvement, wrinkle reduction, wound healing, and overall cell regeneration across the full face, neck, and back of hand.

A complex of H-HA and L-HA (67.5mg each) plus PDRN (5mg) and PN (5mg) per 5mL, combining HA hydration with PDRN/PN cell regeneration.

The overall effect lasts 4 to 8 months, with PDRN/PN action visible in 1-2 weeks, following a cycle of 3 treatments at 2-week intervals.

It is strictly for professional medical use and must not be injected intravascularly.

It is manufactured by Healink Korea.

• Sodium Hyaluronate (H-HA + L-HA): Dual molecular weight HA delivers intensive hydration and elasticity improvement across multiple skin layers simultaneously.
• Polynucleotide: Supports skin regeneration at a cellular level and stimulates natural collagen synthesis.
• Tranexamic Acid & Niacinamide: Reduce pigmentation, strengthen the skin barrier, and promote a brighter, more even complexion.
• Glutathione: Provides powerful antioxidant protection to defend against free radical damage and dullness.
• Recombinant Collagen: Enhances dermal firmness and structural integrity. Active ingredients are delivered directly into the dermis to revitalize the complexion.

• Intense moisture boost and improved skin elasticity
• Enhanced natural glow and skin brightness
• Improved skin clarity and even skin tone
• Supports skin regeneration and firming

• Protect from direct light.
• Do not freeze.
• Sterile product — do not reuse syringes.

• Avoid intense heat and strenuous exercise for a few days following treatment.

PLA (Poly-L-Lactic Acid), PN (Polynucleotides), NAD-(NMN), HA (Hyaluronic Acid), Niacinamide, Vitamin B2, and Succinic Acid.

A multi-modal biostimulator that shifts beyond simple filling by delivering instant improvements in skin quality alongside long-lasting structural remodeling and cellular repair.

• Immediate deep hydration and radiant glow.
• Long-term structural volumization and increased dermal density.
• Skin regeneration and enhanced cellular energy.
• Brightening and antioxidant protection.

• Face: Neck wrinkles, forehead lines, frown lines, crow's feet, and marionette lines.
• Eyes: Dark circles, eye wrinkles, and eye bags.
• Body: Wrinkle care, tightening, cellulite, stretch marks, and brightening for areas like hands, knees, elbows, and armpits.

Onset: Immediate hydration and optical smoothness from HA.
Duration: Gradual accumulation of new collagen and elastin over weeks to months, providing long-term volumization.

Typically 24-36 months from the manufacturing date. Once reconstituted, the solution should be used immediately.

• Side Effects: Mild swelling, redness, bruising, or tenderness at the application sites.
• Post-Care: Apply sunscreen diligently. Avoid excessive heat exposure (e.g., saunas) and strenuous physical activity for a few days post-treatment.

It is a multi-modal biostimulator for immediate hydration and glow, long-term structural volumization, skin regeneration, and brightening across the face, eyes, and body.

PLA (Poly-L-Lactic Acid), PN (Polynucleotides), NAD-(NMN), HA (Hyaluronic Acid), Niacinamide, Vitamin B2, and Succinic Acid.

Shake the vial by hand for 1 minute to reconstitute the lyophilized powder; once reconstituted, the solution should be used immediately.

Strictly for professional medical and aesthetic use, administered into the dermal/subcutaneous layer; do not inject intravascularly.

• PN (Polynucleotide): Fills in and strengthens thin, stretched skin while actively regenerating the skin barrier at a cellular level.
• HA (Hyaluronic Acid, 1.4M Da): Protects the skin barrier and provides intensive, long-lasting moisture retention.
• MGF Multi Growth Factor Complex: A biomimetic blend of 40 active ingredients optimized for skin cell regeneration, tissue repair, and metabolic support.

• Skin moisturization and deep hydration
• Texture improvement and pore tightening
• Elasticity improvement and anti-aging effects
• Skin regeneration and wound healing support
• Sebum reduction for balanced skin condition

• 1 Prepare the skin for absorption using the appropriate aesthetic device (Fraxel Laser / EL / Sonophor).
• 2 Apply PN BOOSTER evenly to the treatment area.
• 3 Apply REVS Gel Mask and leave on for 10–15 minutes.
• 4 Finish by applying REVS Repairing Serum to lock in active ingredients.

• Protect from direct sunlight.
• Do not freeze.

• 1 Apply REVS Hydrating Gel Mask for 10–15 minutes to provide immediate soothing relief to irritated skin.
• 2 Follow with REVS Repairing Serum to hold active ingredients onto the skin and support recovery.

PDLLA acts as an internal biostimulator, triggering fibroblasts to produce collagen and elastin to rebuild the skin's foundational structure. CMC functions externally to enhance viscosity, ensure stable and uniform delivery of particles, and significantly reduce migration risk.

• 1 BPPT Technology (Biostimulator Particle Processing Technology) — produces uniform microspheres precisely controlled to 20–40 µm, minimizing risks of clumping, blockage, nodules, and granulomas.
• 2 D- & L-Isomer Blend — lower crystallinity with controlled biodegradation for smoother, more predictable results.
• 3 GRAS-Certified U.S. Raw Materials — manufactured to the highest safety standards in a Korean GMP sterile facility.

• Collagen regeneration from within for deep skin enhancement
• Long-lasting volume restoration and structural support
• Improved skin elasticity and overall texture
• Facial contour enhancement and definition

• 1 Mix with sterile distilled water and 1–2% lidocaine. Do not use saline — CMC does not dissolve properly in saline.
• 2 Mix using one of the following methods: electric shaker for 15–20 min, manual shaking for 20–30 min, or a 3-way connector.
• 3 Confirm a fully dissolved gel with no visible particles before use.
• 4 Remove only the external white cap. Do not open the vial body directly to preserve sterility.

• Never open the vial body — preserving sterility requires only the external white cap to be removed.
• Avoid creating air bubbles during the shaking or mixing process.

• Early volume loss (Days 3–5): Normal and expected for PDLLA — volume is restored after 3–4 weeks as collagen production begins.
• Adverse event risk: <0.1% — attributed to refined particle uniformity and CMC stabilization.

• Product cannot be dissolved with saline if removal is required. Use HIFU, ultrasound, or laser modalities instead.